MovDisordV3, Main, Exploration, bibRecord, 001005

Rate of Change in Early Huntington's Disease: a Clinicometric Analysis

Identifieur interne : 001005 ( Main/Exploration ); précédent : 001004; suivant : 001006

Rate of Change in Early Huntington's Disease: a Clinicometric Analysis

Auteurs : Christina Meyer [Allemagne] ; Bernhard Landwehrmeyer [Allemagne] ; Carsten Schwenke [Allemagne] ; Adam Doble [France] ; Michael Orth [Allemagne] ; Albert C. Ludolph [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0106503

Descripteurs français

Pascal (Inist)
- Chorée de Huntington, Pathologie du système nerveux, Essai clinique.

English descriptors

KwdEn :
- Clinical trial, Huntington disease, Nervous system diseases.

Abstract

Sensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3-year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of "no" responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional capacity score). In contrast, there was little evidence for progression of the behavioral assessment score over the study period, whereas the cognitive assessment score was intermediate. Twenty-two motor-score items showed linear progression, with a slope of >0.003. These included all chorea items, finger tapping and pronation/supination (left and right), gait, tongue protrusion, and tandem walking. Different symptom domains and individual items evolved at different rates in this group of patients suffering from early HD. It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000296
to stream PascalFrancis, to step Curation: 002A18
to stream PascalFrancis, to step Checkpoint: 000078
to stream Main, to step Merge: 001057
to stream Main, to step Curation: 001005

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Rate of Change in Early Huntington's Disease: a Clinicometric Analysis</title>
<author><name sortKey="Meyer, Christina" sort="Meyer, Christina" uniqKey="Meyer C" first="Christina" last="Meyer">Christina Meyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>SCO:SSiS</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Foxymed</s1>
<s2>Fresnes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Fresnes</wicri:noRegion>
<wicri:noRegion>Foxymed</wicri:noRegion>
<wicri:noRegion>Foxymed</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0106503</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0106503 INIST</idno>
<idno type="RBID">Pascal:12-0106503</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000296</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002A18</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000078</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Meyer C:rate:of:change</idno>
<idno type="wicri:Area/Main/Merge">001057</idno>
<idno type="wicri:Area/Main/Curation">001005</idno>
<idno type="wicri:Area/Main/Exploration">001005</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Rate of Change in Early Huntington's Disease: a Clinicometric Analysis</title>
<author><name sortKey="Meyer, Christina" sort="Meyer, Christina" uniqKey="Meyer C" first="Christina" last="Meyer">Christina Meyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>SCO:SSiS</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Foxymed</s1>
<s2>Fresnes</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Fresnes</wicri:noRegion>
<wicri:noRegion>Foxymed</wicri:noRegion>
<wicri:noRegion>Foxymed</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term>
<term>Huntington disease</term>
<term>Nervous system diseases</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term>
<term>Pathologie du   système nerveux</term>
<term>Essai clinique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3-year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of "no" responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional capacity score). In contrast, there was little evidence for progression of the behavioral assessment score over the study period, whereas the cognitive assessment score was intermediate. Twenty-two motor-score items showed linear progression, with a slope of >0.003. These included all chorea items, finger tapping and pronation/supination (left and right), gait, tongue protrusion, and tandem walking. Different symptom domains and individual items evolved at different rates in this group of patients suffering from early HD. It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Berlin</li>
<li>District de Tübingen</li>
</region>
<settlement><li>Berlin</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université d'Ulm</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Meyer, Christina" sort="Meyer, Christina" uniqKey="Meyer C" first="Christina" last="Meyer">Christina Meyer</name>
</region>
<name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name>
<name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
<name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name>
<name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name>
</country>
<country name="France"><noRegion><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001005 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001005 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0106503
   |texte=   Rate of Change in Early Huntington's Disease: a Clinicometric Analysis
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Rate of Change in Early Huntington's Disease: a Clinicometric Analysis

Rate of Change in Early Huntington's Disease: a Clinicometric Analysis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri